93rd Canadian Chemistry Conference and Exhibition


Biological and Medicinal Chemistry

Sunday PM

BM3Room 203 A

Bioorganic Chemistry (A Symposium Celebrating Ron Kluger's 65th Birthday)

Organizer(s) - Andrew Woolley
Chair(s) - A. Woolley

13:40 00278 Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases *$Silverman R.B.
14:20 00279 Hydrogen Bonds in Synthesis, Molecular Recognition and Catalysis *$Chin J., Kim H., Mui L., So S.
14:40 00280 Organosulfates: Their Synthesis and the Enzymes that Process Them *$Taylor S.D.
15:00 00281 Measurement of Kinetic Isotope Effects on Sialidase Catalyzed-Hydrolysis Reactions with Natural Substrate Analogues Chan J., *Bennet A.J.
15:20 00282 Movement of Subtituents Around Stereocenters During Catalysis by Racemases and Epimerases *$Bearne S.L.
15:40 Coffee Break
Bernard Belleau Award Lecture

16:00 00283 Studies on, and the Manipulation of, Enzymes Involved in Alkaloid and Sialic Acid Biosynthetic Pathways Tanner M.E.
16:40 00284 Investigating the Structural Elements Leading to Efficient Dinuclear Zn(II) Complexes that Catalyze the Cleavage of Phosphate Diesters Mohamed M.F., Neverov A.A., $Brown R.S.
17:00 00285 Activity-based Proteome Profiling of Hepatitis C Virus Replication: Newly Discovered Roles of Host Cell Hydrolase Enzymes in the Viral Life Cycle* *$Pezacki J.P., Blais D.R., Singaravelu R., Qian Y., McKay C.S.
17:20 00286 It's So Hard to Let Go: Staged Product Release in the MurA Catalytic Mechanism *$Berti P.J., Jackson S.G., Chindemi P., Zhang F., Junop M.S.
17:40 00287 Accelerating Decarboxylation in Enzymic Intermediates - The Importance of Overcoming Internal Return of CO2 *$Kluger R., Mundle S.O.C.
18:00 End of Session

BM4Room 205 C

Cancer Therapeutics (joint with OR1)

Organizer(s) - Louise Edwards; David Uehling; Methvin Issac
Chair(s) - L. Edwards

13:40 00288 Developing Potent and Selective Inhibitors of Oncogenic STAT3 Function in Human Cancers *$Gunning P.T.
14:20 00289 SH2 Domain Proteomimetics as Potent Disruptors of a Clinically-Relevant Oncogenic Protein-Protein Interaction Drewry J.A., $Gunning P.T.
14:40 00290 A Peptidomimetic STAT3 Inhibitor Sensitizes Human Prostate Cancer Cells to Chemotherapeutic Treatment: A Promising Synergistic Combination Strategy Shahani V.M., Fletcher S., Sharmeen S., Sukhai M.A., Yue P., Luu D.P., Schimmer A.D., Turkson J., *$Gunning P.T.
15:00 00291 Designed Molecular Hybrids as Improved Anticancer Agents Gleason J.L.
15:20 00292 Direct Evidence of Formation Mechanism of the Self-Assembled Uniform-Size Unilamellar Liposomes for Delivery Carriers *$Nieh M.-P., Mahabir S., Wan W., Katsaras J.
15:40 Coffee Break
16:00 00293 6-Ethynylthieno[3,2-d]- and 6-Ethynylthieno[2,3-d]pyrimidin-4-anilines as Tunable Covalent Modifiers of ErbB Kinases Uehling D.E.
17:00 00295 Novel Inhibitors of Human Farnesyl Pyrophosphate Synthase; in Silico Design, Synthesis and Biological Evaluation *De Schutter J.W., $Tsantrizos Y.S.
17:20 00296 Design and Optimization of Effective Platinum(II)-based G-Quadruplex DNA Binders as Anticancer Therapeutics Castor K.J., *Kieltyka R., $Sleiman H.F.
17:40 00297 The Effect of Serum Protein Binding on the Reduction and Activity of Ruthenium(III) Anti-Cancer Agents Webb M.I., *$Walsby C.J.
18:00 End of Session


Monday AM

BM3Room 203 A

Bioorganic Chemistry (A Symposium Celebrating Ron Kluger's 65th Birthday)

Organizer(s) - Andrew Woolley
Chair(s) - A. Woolley

08:00 00488 Combining Isothermal Titration Calorimetry and NMR Spectroscopy to Identify Binding Cooperativity from an Induced Folding Event in Aminoglycoside N6'-Acetyltransferase-Ii Freiburger L.A., Mittermaier A.K., *$Auclaier K.A.
08:20 00489 Novel Redox Reactions of the Enzyme Cytochrome P450cam: Elucidation of the Role of Water in the Reduction Reaction Prasad B., *$Plettner E.
08:40 00490 Harnessing the Power of P450 Catalyzed Hydroxylations at Inactivated C-H Bonds *Larsen A.T., $Auclair K.
09:00 00491 Choreographing Radical Propagation in a B12 and B6-dependent Enzyme *Wolthers K.R., Levy C., Scrutton N.S., Leys D.
09:20 00492 Surrogates of 17b-estradiol as Potential Carrier Molecules for Nitrogen Mustard DNA Alkylating Agents *$Bérubé G., Descôteaux C., Asselin É.
Boehringer Ingelheim Award Lecture

09:40 00493 Mechanisms and Engineering of Glycosyltransferases Lairson L.
10:00 Coffee Break
10:20 00494 Development of a Novel Class of Inhibitor Against a-Carboxyketose Synthases Balachandran N., *$Berti P.J., Junop M.S.
10:40 00495 Investigating RebC-Mediated Chemoselective Oxidation during Rebeccamycin Biosynthesis Groom K.A., Snieckus V., Zechel D.
11:00 00496 Constrained Mimics of Gypsy Moth Pheromone: Design and Biological Activity *$Plettner E., Chen H.
11:20 00497 Low Km/low kcat Substrates for b-lactamases can Enhance the Potency of Carbapenems Against Antibiotic Resistant Bacteria Marrone L., Goodfellow V.J., Ghavami A., Johnson J.W., Clarke A.J., Viswanatha T., *$Dmitrienko G.I.
11:40 00498 Kinetic Tuning of FAD Semiquinone Stability in Photolyases and Cryptochromes Damiani M.J., *$O'Neill M.A.
12:00 00499 Real-Time Visualization of the Role Lipid Composition, Membrane Structure and Antioxidant Chemical Structure Play in the Radical Scavenging Activity of a-tocopherol Krumova K., Freidland S., $Cosa G.
12:20 End of Session

BM4Room 205 C

Cancer Therapeutics (joint with OR1)

Organizer(s) - Louise Edwards; David Uehling; Methvin Issac
Chair(s) - L. Edwards

08:00 00500 Early Stage Kinase Drug Discovery: Strategies for the Design of Novel Kinase Inhibitor Templates Drewry D.H.
08:40 00501 Development of Novel Selective Estrogen Receptor Modulators *$Jha A.
09:00 00502 Novel Non-carcinogenic Estrogen Compounds for Hormone Replacement Therapy *Wright J.S., Shadnia H., Durst T., Asim M., Pratt M.A.C., O'Brien P.J., Katzenellenbogen J.A.
09:20 00503 PARACEST MRI Contrast Agents toward the Detection of Temperature, pH and Enzymatic Activity *Suchy M., Li A.X., Ta R., Pasternak S.H., Bartha R., $Hudson R.H.E.
09:40 00504 A Novel Approach to Disrupting the Action of Histone Methyltransferases in Cancer: Disruption of Effector Protein-Trimethyllysine Interactions *Hof F., Beshara C.S., Daze K.D., Pinter T., Jones C.E., Jana S.
10:00 Coffee Break
10:20 00505 The Kinamcycins and Isoprekinamycin: Antitumour Antibiotics with a Potentially Novel Mode of Action *$Dmitrienko G.I.
11:00 00506 pH-Responsive Molecular Tweezers *$Chain J.L., Gao H., Petitjean A., Leroux J.-C.
11:20 00507 Discovery of Novel ODCase Inhibitors as Anticancer Agents *$Kotra L.P., Paige C.J., Konforte D., Bello A.M., Pai E.F.
11:40 00508 Enaminones (b-aminovinyl ketones) as Potential New Anti-Cancer Molecules *$Culf A.S., Cuperlovic-Culf M., Ouellette R.J.
12:00 00509 Imide-substituted 4-pyrones as Inhibitors of E1 Ubiquitination Wood T.E., *Batey R.A., $Schimmer A.D.
12:20 End of Session


Monday PM

BM1Room 205 A

Bioinorganic Chemistry (joint with IN2)

Organizer(s) - Deborah Zamble
Chair(s) - D. Zamble

14:00 00854 Investigation on the Metalloenzyme Glyoxalase I from Clostridium acetobutylicum $Suttisansanee U., Lau K., Lagishetty S., Rao K., Swaminathan S., Burley S., *Honek J.
14:20 00855 SlyD: A Ni(II)-binding Protein in Hydrogenase Biosynthesis *Kaluarachchi H., $Zamble D.B.
14:40 00856 The Metal-Binding Properties of the Helicobacter Pylori Hydrogenase Maturation Factor HypB Sydor A.M., Lui J., *$Zamble D.B.
15:00 00857 Bacterial Metal Detectors Structure-Function Relationships in Nickel-responsive Transcriptional Regulators *$Chivers P.T.
15:40 Coffee Break
16:00 00858 Escherichia coli Nickel Regulatory Protein NikR: An Inorganic Playground Phillips C.M., Schreiter E.R., Stultz C.M., *$Drennan C.L.
16:40 00859 The pH- and Nickel- Effects on Helicobacter pylori NikR Li Y., $Zamble D.B.
Strem Chemicals Award for Pure or Applied Inorganic Chemistry Lecture - Monday, 17:00, Room 205 B D

17:00 End of Session

BM5Room 205 C

Carbohydrate Chemistry and Glycobiology (joint with OR2)

Organizer(s) - Mark Nitz
Chair(s) - M. Nitz

13:40 00860 Campylobacter jejuni Capsule Polysaccharides and Their Use in a Multivalent Glycoconjugate Vaccine DePass C., Bertolo L., Ma Z., Chen Y., Boncheff A., Guerry P., Monteiro M.A.
14:00 00861 Approaches to Anti-Cancer Vaccines: Synthesis and Molecular Modeling of dimLex and LeaLex Fragments and Analogues *Auzanneau F.-I., Cheng A., Hendel J., Jackson T., Wang A., Wang J.-W.
14:40 00862 Tempo-mediated Glycoconjugation: A New Scheme for Glycoconjugate Vaccine Synthesis Ma Z., Bertolo L., Arar S., *Monteiro M.A.
15:00 00863 Vaccines are Powerful Tools for Disease Prevention and Therapy Andreana P.R.
15:40 Coffee Break
16:00 00864 Insights into the Structure and Specificity of the Mammalian Neuraminidase 3 (Neu3) Through Site Directed Mutagenesis and Kinetic Studies *$Cairo C.W.
16:40 00865 In Vitro Characterization of E. coli PgaB, an Enzyme Essential for Biofilm Formation Poloczek J., $Nitz M.
17:00 00866 The Characterization of Carbohydrate Binding Site of C. difficile Toxins Using Synthetic Carbohydrates *Ling C., Zhang P., Ng K,
17:20 00867 Mechanistic Evaluations of a-Galactosidases Chakladar S., *Cheng L., $Bennet A..J.
17:40 00868 Active Site 18F labelling and In Vivo PET Imaging of CerezymeÓ, the Glycosylated Enzyme used to Treat Gaucher Disease Phenix C.P., Rempel B.P., Colobong K., Doudet D.J., Adam M.J., Clarke L.A., Withers S.G.
18:00 End of Session

BM9Room 203 A

Nucleic Acids Chemistry

Organizer(s) - Philip Johnson
Chair(s) - P. Johnson

13:40 00869 Progress Towards the Rational and Modular Design of Small Molecules Targeting RNA $Disney M.D.
14:20 00870 Riboswitches as Molecular Regulators and Genetic Tools Caron M.P., Mulhbacher J., *$Lafontaine D.A.
15:00 00871 RNA Dynamics in Purine Riboswitches Prychnya O., Dahabieh M.S., *$O'Neill M.A.
15:20 00872 Using a Riboswitch to Monitor Coenzyme B12 Levels in Living Cells Fowler C.C., Brown E.D., *$Li Y.
15:40 Coffee Break
16:00 00873 Biophysical and Structural Investigations of the Neurospora VS Ribozyme *$Legault P., Bonneau E., Bouchard P., Delfosse V., Desjardins G., DiTomasso G., Girard N., Lacroix-Labonté J.
16:40 00874 Higher-order Structure of RNA by MS-based Approaches *$Fabris D.
17:20 00875 Chemical Probing of Hammerhead Ribozyme Structure and Mechanism Thomas J.M., *$Perrin D.M.
17:40 End of Session


Tuesday AM

BM1Room 205 A

Bioinorganic Chemistry (joint with IN2)

Organizer(s) - Deborah Zamble
Chair(s) - X. Zhang

08:40 01012 Enzyme-Mediated Sol-Gel Processing of Alkoxysilanes: The Enzymatic Cleavage of Silicon-Oxygen Bonds Frampton M.B., Simionescu R., Dudding T., *$Zelisko P.M.
09:00 01013 Predicting 29Si NMR Spectra *$Mawhinney R.C.
09:20 01014 Mercury on the Brain: Toxicological Insights from X-ray Absorption Spectroscopy and Imaging of Human Brain Tissue Korbas M., O’Donoghue J.L., Watson G.E., Pickering I.J., Singh S.P., Myers G.J., Clarkson T.W., *$George G.N.
10:00 Coffee Break
10:20 01015 Bacterial Cytochrome c Peroxidases: A Closed Case? $Elliott S.J., Becker C.F., Ellis K.E., Pulcu G.S., Watmough N.J.
11:00 01016 Mechanism of Metal Ion Inhibition in Ribonuclease t1 *$Khajehpour M., Beauchamp D.
11:20 01017 Metal Induced Oxidation of Met(35) in Amyloid-b Protein Karunakaran-Datt A., *$Kennepohl P.
12:00 01018 Heme and the Amyloid Beta Peptide: Is there another Player in Alzheimer's Redox Game? Wandimagegn T.H., Torres J.A., *$Rauk A.
12:20 End of Session

BM2Room 202 B

Biomaterials and bioanalysis (joint with AN3)

Organizer(s) - Shana O. Kelley; Kagan Kerman
Chair(s) - K. Kerman; S.O. Kelley

09:20 See AN3

12:20 End of Session

BM5Room 205 C

Carbohydrate Chemistry and Glycobiology (joint with OR2)

Organizer(s) - Mark Nitz
Chair(s) - M. Nitz

08:00 01019 Synthesis of Tumor Associated Carbohydrate Antigens LeaLex Fragments Towards its Total Synthesis Guillemineau M., *Auzanneau F.-I.
08:20 01020 Single-Cell Resolution Profiling of Escherichia coli Strains Using Lectins Conjugated to Lanthanide-Chelating Polymers Leipold M.D., Ornatsky O., Baranov V., *$Nitz M.
08:40 01021 Profluorophore Bioorthogonal Labeling Strategies for Cell Surface Glycoconjugates Key J.A., $Cairo C.W.
09:00 01022 The Study of Glycosylation at O-4 of N-acetylglucosamine and its Application in the Synthesis of a Dimeric Lewis X Analogue $Hendel J.L., *Auzanneau F.-I.
09:20 01023 Development of Chemical Tools to Study O-glucosylation of Notch Whitworth G., Zandberg W., Gloster T., Shen D., *$Vocadlo D.
09:40 01024 Novel Route to Nucleosides and Oligonucleotides of Significance in Drug Discovery Prasad A.K.
10:00 Coffee Break
10:20 01025 Enhanced Potencies of Multivalent Carbohydrates in Studies Involving Toxins, Bacteria and Microarrays Pieters R.J.
11:00 01026 Polysaccharide-Block-Polypeptide Block Copolymers as Simple but Functional Glycopeptide Biomimetic Analogues *$lecommandoux S.
11:20 01027 The Effects of Hydroxyproline Glycosylation on the Conformational Stability of the Polyproline II Helix Owens N.W., Bommagani S., Stetefeld J., Lattova E., *$Schweizer F.
11:40 01028 Toward Synthetic Lectins: Design, Synthesis and Screening of a Library of Peptidyl Bis-Boroxoles as Receptors for Complex Oligosaccharides in Water *Hall D.
12:20 End of Session

BM9Room 203 A

Nucleic Acids Chemistry

Organizer(s) - Philip Johnson
Chair(s) - M. Damha

08:20 01029 Minimally Modified Fluorescent Nucleobases: Synthesis and Applications *$Hudson R.H.E., Dodd D.W., Wojciechowski F., St. Amant A.H.
09:00 01030 New Methods in RNA Oligonucleotide Synthesis Hassler M.R., Reddy N.M.K., *Chan T.-H., $Damha M.J.
09:20 01031 Binding and Repair of DNA Interstrand Cross-Links in a -GNC- Motif by Human O6-Alkylguanine-DNA Alkyltransferase McManus F.P., Noronha A.M., Pegg A.E., *$Wilds C.J.
09:40 01032 Conformational Flexibility of C8-Phenoxyl Nucleotide Adducts Millen A.L., *Wetmore S.D.
10:00 Coffee Break
10:20 01033 The Cpep Chemistry in Oligoribonucleotide Synthesis Tram K., *$Yan H.B.
10:40 01034 Improvements in siRNA-Mediated Gene Silencing Arising From Novel Combinations of DNA and RNA Analogues Deleavey G.F., Watts J.K., Robert F., Alain T., Kalota A., Aishwarya V., Pelletier J., Gewirtz A.M., Sonenberg N., $Damha M.J.
11:00 01035 Altering the Backbone of Oligonucleotide with Heterocyclic Triazoles *$Desaulniers J.-P., Efthymiou T.C., Gong W., Koehler C.
11:20 01036 Template Synthesis of Metal-modified DNA Complexes and Applications in the Construction of Two- and Three-Dimensional Metal-DNA Nanostructures Yang H., Rys A.Z., McLaughlin C.K., Altvater F., Lo P.K., *$Sleiman H.F.
11:40 01037 Aptamer to Ribozyme: Theoretical and Experimental Studies of RNA based Catalysis Dieckmann T.
12:20 End of Session

BMPConstitution Hall

Posters

Organizer(s) - Deborah Zamble
Chair(s) - D. Zamble

From 12:20 until 13:40

Poster sessions are from 12:20 - 13:40 and 17:40 - 19:20.

12:20 01038 Interactions of Antimicrobial Peptide Latarcin with Model Cell Membranes Idiong G., Won A., *$Ianoul A.
12:20 01039 Synchrotron Imaging of Burgess Shale Fossils: Evidence for Biochemical Copper (Hemocyanin) in the Middle Cambrian Arthropod Marrella splendens Pushie M.J., Andrahennadi R., Fu J., Liu D., MacDonald T.C., Singh S., Tse J.J., Wiramanaden C.I.E., Yang S.-I., Pickering I.J., George G.N., *$Pratt B.R.
12:20 01040 Structures of C185S and C185A Mutants of Sulfite Oxidase Reveal Rearrangement of the Active Site: A Combined Crystallography, EXAFS and DFT Study Qiu J.A., Wilson H.L., Pushie M.J., Kisker C., George G.N., *$Rajagopalan K.V.
12:20 01041 Probing the Determinates for Substrate Specificity within Arogenate Dehydrogenase Rachel N., Beaudoin G., $Turnbull J.
12:20 01042 Pattern Based Recognition of Heparin Contaminants by an Array of Self-Assembling Fluorescent Receptors Gómez Biagi R.F., *Jagt R.B.C., $Nitz M.
12:20 01043 Heterogeneous Properties of Individual Molecules of b-Galactosidase from the Thermophilic Bacteria Geobacillus stearothermophilus *$Craig D.B.
12:20 01044 In Vitro and In Silico Enantioselective Transesterification Catalysis by Nanosized Serine Protease Subtilisin Carlsberg in Tetrahydrofuran (THF) Delgado Y., Castillo B., Barletta G., *Griebenow K.
12:20 01045 Complexation of Guanidinium and Biguanide Guests by Cucurbit[7]uril *$Macartney D.H., Hettiarachchi D.S. N., MacGillivray B.C.
12:20 01047 Directed Evolution of a Polysialyltransferase Kwan D.H., Rich J., Chen H.M., *$Withers S.G.
12:20 01048 DNA-Directed Assembly of Soft Nanoparticles Dave N., $Liu J.

Graduate Student Posters - General BM

12:20 01049 The Design, Synthesis and Structure-Activity Relationship (SAR) Studies of 2,4-disubstituted-pyrimidine Derivatives as Cholinesterase (ChE) Inhibitors Mohamed T., *Rao P.N.
12:20 01050 Microfluidic Fluorous Ligand Capture to Obtain Tc-99m Radiopharmaceuticals in High Effective Specific Activity Hicks J.W., *$Valliant J.F.
12:20 01051 Polyketide Synthase Genes in Lichen Fungi *Abdel-Hameed M., $Sorensen J.
12:20 01052 Synthesis of Substituted Methyl Ketones as Inhibitors of Atg4B Nguyen T.G., *Young R.N.
12:20 01053 Investigation of the Bacteriophage Protein HK97 gp74 Moodley S., *$Kanelis V.
12:20 01054 Decoration of Cyclen-Based Ligands by "Click" Chemistry: Toward PARACEST MRI Contrast Agents Milne M., *Suchy M., $Hudson R.H.E.
12:20 01055 A New Apporach in Site-specific Incorporation of Deoxyguanosine C8-Aryl Adducts into Oligonucleotides Omumi A., *Manderville R.A.
12:20 01056 Design, Synthesis and Antibacterial Activity of Microcin J25 Peptide Analogues Soudy R., Wang L., Stiles M., *$Kaur K.
12:20 01057 Coupled Fluorescent Reporter Approach for Measurement of Small Molecule Induced Changes in the Differential Regulation of Operons *Kuryllo K., Brown E., $Li Y.
12:20 01058 The Development of a Novel Fluorescent Supramolecular Biosensor Cao P., Gomez-Giagi R.F., *$Nitz M.
12:20 01059 Structural Studies of the Dual Double Stranded RNA Binding Domain of RDE-4 in C.elegans, a dsRNA Binding Protein Involved in RNA Interference Boodram S., $Johnson P.
12:20 01060 Development of Electron Spectroscopic Imagining Techniques for Determination of Charges on Collagen Monomers Su N., Lin A., *Goh M.C.
12:20 01061 Exploring the Fluorescent Probe Potential of 8-(2"-Benzothienyl)-2'-Deoxyguanosine Schlitt K.M., *Manderville R.A.
12:20 01062 Affinity Purification of Isotopically Labelled RNA and Protein RNA Complexes Serbanescu A., $Johnson P.
12:20 01063 Patterning Protein Nanopatterns using a Novel Double Replication Process and Lift-Off Printing Technique to Investigate Cell Response Ricoult S.G., Safavieh R., Pla-Roca M., Tansky N., *$Juncker D.
12:20 01064 Bis-Tetramers of Hemoglobin as Red Cell Substitutes Vandersteen A.A., Foot J.S., Lui F.E., *$Kluger R.
12:20 01065 Blocking the Nuclear Translocation of Signal Transducer and Activator of Transcription 3 Protein via Membrane Anchorage Avadisian M., *Fletcher S., Liu B., Xu W., Yue P., $Gunning P., Gradinaru C., Schimmer A., Turkson J.
12:20 01066 The Synthesis and Properties of Thymidine-Phenolic DNA Adducts Sproviero M., Manderville R.
12:20 01067 Lanthanum-catalyzed Biomimetic Aminoacylation of Ribonucleosides and Nucleotides with Amino-deprotected Aminoacyl Phosphate Esters Her S., *$Kluger R.
12:20 01068 Cucurbiturils as Drug Reversal Agents Gamal-Eldin M., *$Macartney D.H.
12:20 01069 Towards the Use of Luminescence-based Probes in the Study of Aptamer-Target Binding Bernard E.D., *$DeRosa M.C.
12:20 01070 Cyclobutanone Analogues of b-Lactams: Synthesis, Conformational Properties, and Inhibition of Serine- and Metallo-b-Lactamases Johnson J.W., Gretes M., Marrone L., Goodfellow V.J., Strynadka N.C, *Dmitrienko G.I.
12:20 01071 Strain-Promoted 1,3-Dipolar Cycloadditions of Diazo Compounds with Cyclooctynes McKay C.S., Moran J., *$Pezacki J.P.
12:20 01072 Design and Synthesis of 2,6,9-hetero-trisubstituted Purine Inhibitors of the Stat3-SH2 Domain *Shahani V., Haftchenary S., Lukkarila J., $Gunning P.T.
12:20 01073 Interaction of Small Cationic Antimicrobial Peptides with Model Biomembranes *Balhara V., $DeWolf C., Gorr S.-U.
12:20 01074 Directing Depsipeptide Biosynthesis to Produce "Unnatural" Natural Product Anticancer Agents Torchia J.V., *Wang W., Verma N., $Magarvey N.A.
12:20 01075 Yarn-based Microfluidic Mixers and Circuits Safavieh R., Zhou G., *$Juncker D.
12:20 01076 Characteristics of Oligonucleotides Containing a Novel 1,2,3-triazole Backbone Modification Efthymiou T.C., $Desaulniers J.-P.
12:20 01077 Patterning Protein Nanopatterns using a Novel Double Replication Process and Lift-Off Printing Technique to Investigate Cell Response Ricoult S.G., Safavieh R., Correia J.P., Pla-Roca M., Kennedy T.E., *$Juncker D.
12:20 01078 Analysis of Steroid Binding by a Modified Cocaine-Binding Aptamer Reinstein O., *Neves M., $Johnson P.E.
12:20 01079 Cucurbit[7]uril Complexes of Dimethoxybenzylisoquinoline Alkaloids Kwok J.K., *$Macartney D.H.
12:20 01080 The Development and Applications of Peptidomimetic Ligation Assem N., $Yudin A.K.
12:20 01081 Kinetic Stability of the Flavin Semiquinone in Photolyase and Cryptochrome-DASH Damiani M.J., *$O'Neill M.A.
12:20 01082 Effect of L- to D-Peptide Isomerisation on the Activity of Antimicrobial Peptide Anoplin Won A., Khan M., Gustin S., Akpawu A., Pripotnev S., *$Ianoul A.
12:20 01083 Synthesis of Novel Nucleosides by Photochemical Ring Expansion of Cyclobutanones Lee-Ruff E., Jaffer M.
12:20 01084 Selective Metabolite Detection in Serum with an Immobilized Aptamer Biosensor Huang J., $Liu J.

Bioinorganic Chemistry

12:20 01085 Remarkable Effect of Mobile Phase Buffer on the SEC-ICP-AES Derived Cu, Fe and Zn-Metalloproteome Pattern of Blood Plasma Zeini Jahromi E., Gailer J.
12:20 01086 Serum Protein Interactions and Ligand Effects of Ruthenium(III) Anticancer Agents Webb M.I., *$Walsby C.J.
12:20 01087 Abstraction of Fe3+ and Zn2+ from Metalloproteins by Clinical Iron Chelators in Plasma In Vitro Sooriyaarachchi M.D., Gailer J.
12:20 01088 Theoretical Calculation of the MCD Spectra for Some Molybdenyl Complexes Hernandez-Marin E., Ziegler T.
12:20 01089 A Magnetic and Electronic Circular Dichroism Study of Blue Copper Proteins Based on Time-Dependant Density Functional Theory Calculations $Zhekova H.R., Seth M., *Ziegler T.
12:20 01090 Exploiting Ferrocene Phosphorylations for Protein Immobilization onto Gold Surfaces Shipman P.O., *$Kraatz H.-B.
12:20 01091 Complex Formation between Cysteine and the Antitumor Active Compound Rhodium(II) Acetate Niksirat P., *Jalilehvand F.
12:20 01092 Ferrocene Peptide Conjugates as Alzheimer's Models Beheshti S., *Kraatz H.-B.

Graduate Student Posters - Bioinorganic Chemistry

12:20 01093 YeiR: A Metal Binding GTPase Flood J., $Zamble D.
12:20 01094 Capturing the Nickel Insertion Complex of E. coli [NiFe] Hydrogenase *Chan Chung K.C., $Zamble D.B.
12:20 01095 New Ferrocene-diamine Peptide Conjugates Shen Y., Lataifeh A., *Kraatz H.-B.
12:20 01096 The Enzymatic Cleavage of Si-O Bonds: A 29Si NMR and Computational Analysis of the Trypsin Catalyzed Hydrolysis of Phenyltrimethoxysilane Frampton M.B., Simionescu R., Dudding T., *$Zelisko P.M.
12:20 01097 The Role of Dimerization of Escherichia coli HypB in the Hydrogenase Biosynthesis Cai F., $Zamble D.B.
12:20 01098 Probing the Selectivity of a High-Affinity Metal-Binding Peptide *Douglas C.D., $Zamble D.B.
12:20 01099 Towards a Model for the Rieske Protein Han G.-C., *$Kraatz H.-B., Liu Y.-N.

Biomaterials and Bioanalysis

12:20 01100 Synthesis and Sensing Application of Ferrocene-Biotin Bioconjugates Martic S., $Kraatz H.B.
12:20 01101 Ferrocene-ATP Conjugates as Sensing Probes for Src and Erk Protein Kinase Activity Martic S., $Kraatz H.B.
12:20 01102 Immobilization of Structure-Switching DNA Aptamers onto Sol-Gel Derived Silica for Solid-Phase Biomolecular Detection Carrasquilla C., Li Y., $Brennan J.D.
12:20 01103 A Novel Approach for Detection of Several Tuberculosis Markers Using Diffractive Optics Kim N., *Loo R., $Goh M.C.
12:20 01104 Electrochemical Detection of Cancer Markers based on Nanostructured Microelectrodes Das J., Lam B., Sargent E.H., *$Kelley S.O.
12:20 01105 Electrochemical Detection of Clinically Significant Proteins Labib M., Modupeola S., Lataifeh A., López B.P., *Kraatz H.-B.
12:20 01106 Monitoring SRC Kinase Activity Using Ferrocene- conjugated ATP Almostafa M.A., Matric S., *$Kraatz H.-B.
12:20 01107 Development of a Bioactive Lab-on-Paper Sensor for the Detection of E. Coli Based on -Glucuronidase Activity Ozimok C.J., Hossain S.M.Z., *Brennan J.D.
12:20 01108 Novel Blocking Agents from High Throuhput Screening Wang J., Brennan J., Pelton R.
12:20 01109 Using Magnetic Beads in Mixture Screens for Modulators of Protein-Protein Interactions $McFadden M.J., Junop M.S., *Brennan J.D.
12:20 01110 Discrimination of the Single Nucleotide DNA Mismatches at Different Sequence Positions by Electrochemical Impedance Spectroscopy *Shamsi M.H., $Kraatz H.B.
12:20 01111 Targeting Intracelluar Double-Stranded RNAs with a Small FRET Molecule: FLeth Qian Y., *$Pezacki J.P.
12:20 01112 High-quality Screening of Pharmaceutical Chaperones by Capillary Electrophoresis Shanmuganathan M., *Britz-McKibbin P.
12:20 01113 Collagen Films Loo R.W., $Goh M.C.
12:20 01114 A New Fluorimetric Acetylcholinesterase Assay Compatible with Microarray Format for Inhibitor Screening Monton M.R.N., Lebert J.M., Little J., $Brennan J.D.
12:20 01115 Small Molecule Screening via Bioaffinity nanoLC-MALDI Tandem Mass Spectrometry Smith A.M.E., Brennan J.D.

Graduate Student Posters - Biomaterials and Bioanalysis

12:20 01116 Spectrally Distinct Calcium Ion Biosensors based on Novel Fluorescent Proteins Ding Y., Ai H., *$Campbell R.
12:20 01117 A Gold Nanoparticle-based Device for Mapping Protein S-nitrosylation Faccenda A.C., Bonham C., Durocher S., Zhang X., *$Mutus B.
12:20 01118 Rapid, Sensitive, and Direct Bacterial Detection on Chip-based Hierarchical Nanotextured Microelectrodes Fang Z., Soleymani L., Lam B., Bin X., $Sargent E.H., *Kelley S.O.
12:20 01119 Localized Surface Plasmon Resonance-based Biosensors for the Detection of Biomolecular Interactions $Veloso A.J., Cheng X.R., Ushijima H., Tamiya E., *Kerman K.
12:20 01120 Covalent Immobilization of Growth Factors for Vascular Tissue Engineering Chiu L.L., Chiang C.K., Chowdhury M.F., Stanford W.L., *$Radisic M.
12:20 01121 Rational Manipulation of Amyloidogenesis using Fibril Interactions in Wild-type TTR105-115 $Liang Y., Jasbi S., Morin S., *Wilson D.

Cancer Therapeutics

12:20 01122 Blocking the Nuclear Translocation of Signal Transducer and Activator of Transcription 3 Protein via Membrane Anchorage Avadisian M., *Fletcher S., Liu B., Xu W., Yue P., $Gunning P., Gradinaru C., Schimmer A., Turkson J.
12:20 01123 Theoretical Predictions Concerning the Three-Dimensional Structures of Lomaiviticins A and B as Potential Guides to the Construction of Simpler but Equipotent Anticancer Agents Chen N., *$Dmitrienko G.I.
12:20 01124 Ten Years of Experience in Heterocyclic Chemistry Synthesis Based on Nitrogen Electron Rich Pyrazole Compounds *Touzani R., El Kadiri S.
12:20 01125 Pericyclic Mechanisms for Reactions of Nitric Oxide with Diazodiphenyl Methane: Insights into the Unusual Properties of the Diazo Groups in Kinamycin and Isoprekinamycin Antitumour Antibiotics Abbott G.L., *$Dmitrienko G.I.
12:20 01126 Design, Synthesis and Biological Evaluation of New (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as Selective COX-2 Inhibitors *$Zarghi A., Arfaie S.
12:20 01127 Conjugation Chemistries for the MRI Contrast Reagent DOTAM-Gly-L-Phe-OH *Suchy M., Li A.X., Milne M., Bartha R., $Hudson R.H.E.
12:20 01128 Synthesis and Evaluation of 1,5-Diaryl-tetrazoles as Novel Cyclooxygenase-2 (COX-2) Inhibitors Jawabrah Al-Hourani B., Sharma S., Suresh M., *Wuest F.
12:20 01129 Design, Synthesis and Biochemical Evaluation of Antiestrogen and Histone Deacetylase Inhibitor Hybrids Mendoza-Sanchez R., Cotnoir-White D., Mader S., *$Gleason J.L.

Graduate Student Posters - Cancer Therapeutics

12:20 01130 Small Molecule Inhibitors of Stat3 as Potent and Selective Anti-cancer Agents Page B.D.G., Schimmer A., Turkson J., *$Gunning P.T.
12:20 01131 pH- Triggered Molecular Drug Carriers Leblond J., Gao H., Cruz C., *$Petitjean A., Leroux J.C.
12:20 01132 Enhancement of Docetaxel Solubility via Conjugation of Formulation-Compatible Moieties Huynh L., Leroux J.-C., Allen C.
12:20 01133 pan-HDAC Fluorescent Inhibitor Synthesis and Application in Fluorescence Polarization-Based High-Throughput Screening Assays Burger M.C., *$Gleason J.L.
12:20 01134 Harnessing Mitochondria-Penetrating Peptides for Delivery of Mitotoxic Compounds Fonseca S.B., Pereira M.P., *$Kelley S.O.

Bioorganic Chemistry (A Symposium Celebrating Ron Kluger's 65th Birthday)

12:20 01135 Cyclization Mechanisms of Type III Polyketide Synthases Posehn S., Suh D.-Y., Wee A.G.H.
12:20 01136 Investigating the Mechanism Underlying Substrate and Product Movement within STS using Photoaffinity Labels Phan C., Nicholas C., *$Taylor S.
12:20 01137 Controllable Delivery of Small Molecules to Targeted Cells Utilizing Single-walled Carbon Nanotubes Su Z., Zhu S., Donkor D., Tzogankis C., $Honek J.F.
12:20 01138 Fighting Aminoglycoside Resistance: Strategies, Syntheses, and Applications Vong K, $Auclair K
12:20 01139 Optimized Synthesis and Stability Study of a Ring Locked Retinoid Cote J.B., Quach T.Q., Demenev A., *$Berman J.
12:20 01140 Synthesis and Conditions for Facile Z to E Isomerism of Chromogenic b-lactamase Substrates and Inhibitors Ghavami A., Marrone L., Goodfellow V.J., Viswanatha T., *$Dmitrienko G.I.
12:20 01141 Towards the Site-specific Bioconjugation of P450 Enzymes Menard A., $Auclair K.
12:20 01142 Characterizing the Fosfoymcin-Resistant Enolpyruvyl-UDP-GlcNAc Synthase (MurA) from Lyme Disease Jiang S., MacKeracher K., Gilpin M., Attia M., *$Berti P.J.
12:20 01143 Inhibition of Helicobacter pylori Aminoacyl-tRNA Amidotransferase by Puromycin and Chloramphenicol Analogues De Mieri M., Balg C., Huot J.L., Blais S., Lapointe J., *Chênevert R.
12:20 01144 Recent Progress in the Antibacterial Properties of Kinamcyins: Discovery of b-lactamase Inhibitory Properties Goodfellow V.J., Ghavami A., Krismanich A., Adedayo O., Marrone L., *$Dmitrienko G.I.
12:20 01145 Regio- and Stereo-Selective Transfromations of Bicyclo[3.2.0]heptan-6-ones: Potential Carbocyclic Inhibitors for b-Lactamases Krismanich A., Thandi M.S., Johnson J.W., *$Dmitrienko G.I.
12:20 01146 Design and Characterization of a Genetically Encoded Photoswitchable DNA Binding Protein Morgan S., Woolley G.A.
12:20 01147 Insight into the Structure-Activity Relationship of Enantiomeric Schiff Bases Derived from S-Substituted Dithiocarbazate Tan S.-L., *Crouse K.A., Mohammed Tahir M.I., Rosli R.

Graduate Student Posters - Bioorganic Chemistry

12:20 01148 A Biocompatible Ligation: 1,3-Dipolar Cycloaddition Reaction Between Phosphoranes and Azides Ahsanullah A., *$Rademann J.
12:20 01149 Investigation into the Turnover of Fluorinated Methionines by Methionine c-Lyase 1 from the Human Pathogen Trichomonas vaginalis Moya I.A., $Honek J.F.
12:20 01150 Probing Signal Transduction in Photoactive Yellow Protein Using Site-Directed Mutagenesis Kane L.E., $Woolley G.A.
12:20 01151 Recognition Loop Kinetics of a Photolyase and Cryptochrome-DASH $Brolich M.A., Wang L, Mcleod N.R., Damiani M.J., *O'Neill M.A.
12:20 01152 Analysis of Photocontrolled DNA Binding by a Series of GCN4-PYP Mutants Fan H.Y., Morgan S.A., *$Woolley G.A.

Nucleic Acids Chemistry

12:20 01153 Short Interfering RNA Duplexes Incorporating 6-phenylpyrrolocytidine Azizi F., Wahba A., $Damha M.J., Hudson R.H.E.
12:20 01154 Building 3D Nanostructures via Supramolecular DNA Assembly Hamblin G.D., McLaughlin C.K., Aldaye F.A., Yang H., $Sleiman H.F.
12:20 01155 Role of Pseudohydrogen (Fluorine-Hydrogen) Bonding in the Stabilization of Nucleic Acid Double Helices Yahyaee M., Watts J.K., *$Damha M.J.
12:20 01156 Structural and Biophysical Characterization of Viral Nucleic Acid Binding Proteins Xiong S., van Dijk C., *$McKenna S.A.
12:20 01157 Heterocycle-Appended Cytidines as Base-Discriminating Fluorophores, Hydrogelators and Post-Synthetic Labels Dodd D.W., Schulman J.M., *$Hudson R.H.E.
12:20 01158 Synthetic Branched RNA Fragments as Powerful Probes for Characterization and Crystallization of the Debranching Enzyme Katolik A.K., Montemayor E.M., Hart J.H, *$Damha M.J.D.

Graduate Student Posters - Nucleic Acids Chemistry

12:20 01159 In Vitro Selection of a DNA Aptamer for Homocysteine McKeague M., *$DeRosa M.C., Foster A., Chan J.
12:20 01160 Synthesis and Photo-Isomerization Studies on a Peptide Nucleic Acid Monomer Bearing the Dimethylaminophenylazobenzene Moiety Moustafa M., *Hudson R.
12:20 01161 Three Dimensional (3D) DNA Nanostructures: Site-Selective Incorporation of Transition Metals, Nanocrystals and Biomolecules Mclaughlin C.K., Yang H., Hamblin G.D., Rys A.Z., Bouten P., Aldaye F.A., Rouiller I., $Sleiman H.F.
12:20 01162 Tuning DNA Self-assembly with Small Molecules: Error-correction and Surface-directed Organization with Ruthenium(II) Tris(bipyridine) and Cyanuric Acid Greschner A., Hamblin G., Aldaye F., $Sleiman H.
12:20 01163 Synthesis of Cyclic Dinucleotide Analogues Wang X., Li J., $Chen W., *Yan H.
12:20 01164 Synthesis of Purine and Pyrimidine Dimers Bridged by a Triazole Backbone Modification Koehler C., *Gong W., $Desaulniers J.-P.
12:20 01165 Towards the Development of an Aptamer-based System for Rapid Identification of Gastroenteric Viruses Giamberardino A., Sattar S., Springthorpe S., Mattison K., *$DeRosa M.C.
12:20 01166 Synthesis of Asymmetrical DNA Duplexes Containing N3-2'-Deoxythymidine-Butyl-N3-2'-Deoxythymidine Interstrand Cross-Links Sun G., Noronha A.M., *$Wilds C.J.

Protein Design and Engineering

12:20 01167 The bZIP can Complex with DNA via a Sliding Mechanism *Chan I.-S., Al-Sarraj T., Shahravan H.S., Fedorova A.V., $Shin J.A.
12:20 01168 Investigation of a Homocystinuria-Association Mutations of Residues in the Active Site of Cystathionine b-Synthase Abouassaf E.A., Lodha P.H., *$Aitken S.M.
12:20 01169 Phenylalanine Ammonia Lyase Activity in Ionic Liquids *$D'Cunha G.B., Barron C.C., Sponagle B.J.D.

Graduate Student Posters - Protein Design and Engineering

12:20 01170 Engineering the Viral Suppresor of RNA Silencing Protein P19 as FRET-based Probes for Imaging Protein-small RNA Interactions In Vivo Danielson D.C., Cheng J., Koukiekolo R., Rouleau Y., Jakubek Z.J., *$Pezacki J.P.
12:20 01171 Engineering 'One-Component' Flavin-Dependent Halogenases McSorley F.R., $Zechel D.L.
12:20 01172 Comparative Enzymology on Bifunctional and Monofunctional Forms of Prephenate Dehydrogenase from Haemophilus influenza Reveal the Importance of the Mutase Domain Quashie P.K., *Anani S., $Turnbull J.L.

Carbohydrate Chemistry and Glycobiology

12:20 01173 Carbohydrate and Nucleoside Based Inhibitors of Nucleotidyltransferases Loranger M. W., $Jakeman D.L.
12:20 01174 Towards the Synthesis of a-C-linked Galactosyl-Threonine Glycoconjugates Tam R.Y., Leclère M., Cheema T, $Ben R.N.
12:20 01175 The Total Synthesis of Chondroitin Sulfate-C Ingram L.J., *Taylor S.D.
12:20 01176 Unprotected Synthesis of Novel Carbohydrate-based Inhibitors of Biofilm Formation Chibba A., *Poloczek J., $Nitz M.

Graduate Student Posters - Carbohydrate Chemistry and Glycobiology

12:20 01177 Synthesis of the Disulfated Tetrasaccharide Fragment of SB1a, a Carbohydrate Hapten Associated with Human Hepatocellular Carcinoma Desoky A.Y., *Taylor S.D.
12:20 01178 Ice Recrystallization Inhibition Ability of Functionally Derived Galactosides Tokarew J.M., $Ben R.N.
12:20 01179 Aminoacylation of Carbohydrates in Water Dhiman R., $Kluger R.
12:20 01180 Divergent Synthesis of Hydroxylamine-scyllo-inositol Derivatives as Potential Beta-Amyloid-42 Inhibitors Chio J., $Nitz M.
12:20 End of Session


Tuesday PM

BM1Room 205 A

Bioinorganic Chemistry (joint with IN2)

Organizer(s) - Deborah Zamble
Chair(s) - D. Zamble

14:00 01529 Visualizing Dynamic Bioinorganic Processes Involving Metalloproteins in Blood Plasma by SEC-ICP-AES Gailer J., Sooriyaarachchi M., Zeini Jahromi E.
14:20 01530 Metalation Pathways in Metallothionein Elucidated with Time- and Temperature-resolved ESI-Mass Spectrometry *$Stillman M., Ngu T., Lee J., Rushton M., Pinter T., Easton A.
15:00 01531 Probing and Manipulating Biological Zinc *$Zhang X.-a.
15:20 01532 Copper Coordination Chemistry and its Cellular Consequences Kennedy D.C., McKay C.S., *$Pezacki J.P.
15:40 Coffee Break
16:00 01533 Bioinorganic Chemistry of Titanium in Medicine and the Environment Batchler K.L., Buettner K.M., Cole K.E., Tinoco A.D., Uppal R., Collins J.M., *$Valentine A.M.
16:40 01534 Heme p-Stacking In the Drug Action of the Quinoline Antimalarials Bohle D.S., Dodd E., Kosar A.J., Suarez L., Walczaj M.S., Lawniczak-Jablonska K., Sienkiewicz A., Bellemare M.-J.
17:00 01535 Gallium Analogs of Hemozoin: Modeling Antimalarial Drug Action Dodd E.L., Bohle D.S.
17:20 01536 Ferrocenyl Carbohydrate Chloroquine Conjugates as Potential Antimalarials Herrmann C., Salas P.F., Nimphius C., Adam M., *$Orvig C.
17:40 End of Session

BM2Room 202 B

Biomaterials and bioanalysis (joint with AN3)

Organizer(s) - Shana O. Kelley; Kagan Kerman
Chair(s) - K. Kerman; S.O. Kelley

13:40 See AN3

17:00 End of Session

BM9Room 203 A

Nucleic Acids Chemistry

Organizer(s) - Philip Johnson
Chair(s) - Y. Li; T. Dieckmann

13:40 01537 Functional DNAs and Lipids for Biosensing, Drug Delivery, and Nanotechnology Liu J., Dave N., Huang P.-J., Smith B., Baeissa A.
14:00 01538 Computational Design of Structurally Complex Aptamer Pools McKeague M., *$DeRosa M.C., Dehne F., Luo X.
14:20 01539 Building an Acoustic Wave Cocaine Biosensor Neves M.A.D., Johnson P.E., *$Thompson M.
14:40 01540 The Prevalence and Potential of Two-tiered Guanine Quadruplexes in Functional Nucleic Acids McManus S.A., *$Li Y.
15:00 01541 A Contractile Electronic Switch Made of DNA Sen D., *Huang Y.C.
15:40 Coffee Break
16:00 01542 Making DNAyzmes Work at Cellular Levels of Mg2+ *$Perrin D.M., Hollenstein M., Lam C.H., Hipolito C.J.
16:40 01543 Investigation of DNA-Binding of Vancomycin Resistance Associated Regulator Protein VraR by Atomic Force Microscopy Ore M., Belcheva A., Golemi-Kotra D., *Morin S.
17:00 01544 Binding and Release of the 6S Transcriptional Control RNA Shephard L., Dobson N., *$Unrau P.J.
17:40 End of Session

BM10Room 203 B

Peptides and Their Pharmaceutical Relevance (joint with IC5)

Organizer(s) - Eran Benjamin

13:40 See IC5

17:20 End of Session

BM12Room 205 C

Radiopharmaceuticals (joint with OR9)

Organizer(s) - Neil Vasdev
Chair(s) - N. Vasdev

13:40 01545 Molecular Imaging Biomarkers: Chemical Approaches to Tracer Development *VanBrocklin H.F.
14:20 01546 The Second Avatara of [18F]6-FDOPA: A superior PET-tracer for the Detection of Variety of Neuroendrocrine Tumors in Human Cancer Patients *$Chirakal R.
15:00 01547 Boronic Acids Afford a One Step Labeling of Biomolecules with 18F: Imaging Breast Cancer in Mice *$Perrin D.M., Li Y., Ting R.T., Harwig C., Inkster J., Bellac C., Lange P., auf dem Keller U., Schaffer P., Adam M.J., Ruth T.J., Overall C.M., Dedhar S., Benard F.
15:40 Coffee Break
16:00 01548 Application of Positron-Emitting Radiometals in Cancer Imaging *$Lewis J.S.
16:40 01549 Who Needs Phosgene Anyway? DIrect Fixation of [11C]-CO2 by Amines Wilson A.A., Garcia A., Vasdev N.
17:20 End of Session


Wednesday AM

BM2Room 202 B

Biomaterials and bioanalysis (joint with AN3)

Organizer(s) - Shana O. Kelley; Kagan Kerman
Chair(s) - S.O. Kelley; K. Kerman

09:20 See AN3

12:20 End of Session

BM6Room 203 B

From In Silico to In Vivo: Strategies for Probing Molecular Phenomena at Biological Interfaces (joint with SS2)

Organizer(s) - Chris M. Yip
Chair(s) - C.M. Yip

08:20 See SS2

12:20 End of Session

BM7Room 202 C

General

Organizer(s) - Deborah Zamble
Chair(s) - V. Kanelis

08:20 01678 Search for New Targets to Control Leukotriene Biosynthesis Kumar N.S., Braun M.P., Chaudhary A.G., $Young R.N.
08:40 01679 Reversible Inhibition and Photolabelling of Tissue Transglutaminase Roy I., Leogane O., Pardin C., *Keillor J.W.
09:00 01680 Development of New Dimaleimide Moieties for Specific Fluorogenic Protein Labeling Lachance H., Caron K., *Keillor J.W.
09:20 01681 Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-based Thiophene Amidine Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors Ramnauth J., Speed J., Maddaford S.P., Dove P., Annedi S.C., Renton P., Rakhit S., Andrews J.S., Nair S., Catalano T., Lee D., De Felice M., Porreca F.
09:40 01682 The Discovery of MK-0674, an Orally Bioavailable Cathepsin K Inhibitor *Isabel E.
10:00 Coffee Break
10:20 01683 Pyrogallolarenes as New Anti-HIV-1 Agents *$Nolan K., Carey S., Griffin P., Shattock R.
10:40 01684 Polycationic Amphiphiles with Potent Antibacterial Activity Against Multidrug-Resistant Bacteria and Reduced In Vitro Toxicity Dhondi R., Bera S., *$Schweizer F.
11:00 01685 Serendipity and Molecular Design: Synthesis of a Bicyclo[3.3.0]Sulfone Scaffold for Targeting Drug-Resistant Influenza *$Wulff J.E., Brant M.G., Bromba C.M.
11:20 01686 Nanoscale Amorphous Hemalums: Harmonophore for THG Tokarz D., *Tuer A., Cisek R., $Barzda V.
11:40 01687 Nitrones as Dipoles for Rapid Strain-Promoted 1,3-Dipolar Cycloadditions with Cyclooctynes McKay C.S., *Moran J., $Pezacki J.P.
12:00 01688 AChE Inhibitory Potential of Ferulic Acid, Cinnamic Acid and Artemisinin Isolated from Plants Rehman S., *$Shahwar D., Asam Raza M.
12:20 End of Session

BM11Room 203 A

Protein Design and Engineering

Organizer(s) - Jumi Shin
Chair(s) - J. Shin

08:20 01689 Characterization of Active Site Mutations in a Thermophilic Dehydrogenase Hotz N., $Turnbull J.L.
08:40 01690 Synthesis, Structure and Activity of Sulfur Containing Peptides from Bacteria Vederas J.C.
09:20 01691 Progress Towards the Identification of Unnatural Peptide Ligands to eIF4E *$Desaulniers J.-P., Peterson A.
09:40 01692 Usnic Acid Biosynthesis in Cladonia uncialis *$Sorensen J.L.
10:00 Coffee Break
10:20 01693 Refining the Mechanism of Molecular Recognition Between c-Myc and Max Lavigne P.
11:00 01694 Size Scaling in Single and Multidomain Protiens, the Four Major Structural Classes, and Family Lineages Rogerson P., *$Arteca G.A.
11:20 01695 Generation of Longer Emission Wavelength Red Fluorescent Proteins Using Computationally Designed Libraries *Chica R.A., Moore M. M., $Mayo S.L.
11:40 01696 A Long Diethynyl-substituted Azobenzene Cross-linker for Increasing the Degree of Photo-controlled Protein Structural Change Beharry A.A., Sadovski O., Chen S.B., Fan H.Y., Zhang F., Al-Abdul-Wahid S., Prosser R.S., $Woolley G.A.
12:00 01697 Semi-Synthesis of a-Hemolysin Mutants by Expressed Protein Ligation Boudreau M.A., Cheley S., Daltrop O., Bayley H. WITHDRAWN
12:20 End of Session

BM12Room 205 C

Radiopharmaceuticals (joint with OR9)

Organizer(s) - Neil Vasdev
Chair(s) - D. Hunter; M. Kovacs

08:00 01698 Metalloradionuclide Coordination Chemistry *$Orvig C., Adam M.J.
08:40 01699 Silicon-18F Radiochemistry for the Development of PET Imaging Agents *$Schirrmacher R.
09:20 01700 Radiolabelling an Unprotected b-Amino Acid: Synthesis of [11C]Methylphenidate Moran M.D., Wilson A.A., Stableford W. T., Wong M., Houle S., *$Vasdev N.
09:40 01701 Iozapine: A Potential Dopamine Receptor Imaging Agent *Sharma S.K., Joshua A.V., Silverstone P., Martin-Iverson M.T., Strelkov A., Abrams D.N., McEwan A.J.B.
10:00 Coffee Break
10:20 01702 Imaging as Biomarker to Accelerate Drug Development McCarthy T.J.
11:00 01703 Application of Transition Metals for the Synthesis of 18F-labeled Radiotracers Wuest F.
11:40 01704 Apply "Click-Chemistry" on Aryltrifluoroborates in PET Imaging Li Y., *$Perrin D.M.
12:00 01705 Using Microfluidic Reactors to Prepare Technetium and Fluorine-18 Based Probes Stephenson K.A., Simms R.W., Causey P.W., $Valliant J.F.
12:20 End of Session

BM13Room 202 D

The Chemistry and Biology of Natural Products (joint with OR13)

Organizer(s) - Nathan Magarvey; Paul Harrison
Chair(s) - N. Magarvey

08:00 See OR13

12:20 End of Session


Wednesday PM

BM2Room 202 B

Biomaterials and bioanalysis (joint with AN3)

Organizer(s) - Shana O. Kelley; Kagan Kerman
Chair(s) - S.O. Kelley; K. Kerman

13:40 See AN3

17:20 End of Session

BM6Room 203 B

From In Silico to In Vivo: Strategies for Probing Molecular Phenomena at Biological Interfaces (joint with SS2)

Organizer(s) - Chris M. Yip
Chair(s) - C.M. Yip

13:40 See SS2

15:40 End of Session

BM7Room 202 C

General

Organizer(s) - Deborah Zamble

13:40 01854 Irreversible Sequestering of Cationic Peptides by Heparin $Nitz M., Rullo A.F.
14:00 01855 Brønsted Analysis of a Pseudo-Deglycosylation Reaction: Mechanism of Desialylation in Sialidases Shidmoossavee F.S., *Cheng L., Watson J.N., $Bennet A.J.
14:20 01856 Cloning, Expression and Purification of Human L-glutamine:D-fructose-6-phosphate amidotransferase 1 (hGFAT1), a Novel Target for the Treatment and Prevention of Complications Associated with Diabetes Mellitus Walter L.A., *$Capretta F., Werstuck G.H.
14:40 01857 Synthesis of New Analogs of Selecoxib as Cyclooxygenase 2 (COX-2) Inhibitors *Behravan J., Entezari Heravi R., Hadizadeh H., Tavakol Afshari J., Sankian M.
15:00 01858 Transition-Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (6HM4ETSC) and their Anticancer Activities; Crystal Structures of VO2(6M4ETSC) and Pt(6M4ETSC)Cl Elsayed S.A., El-Hendawy A.M., Mostafa S.I., Jean Claude B.J., Todorova M., Butler I.S.
15:20 01859 Developement of Dual Prodrug Conjugates for the Treatment of Osteoporosis *Arns S., $Young R.N.
15:40 Coffee Break
16:00 01860 Label-free Imaging of Host Lipid Droplets' Dynamic Interactions in Human Hepatoma Cells Expressing HCV Core *Lyn R.K., Kennedy D.K., Ridsdale A., Stolow A., $Pezacki J.P.
16:20 01861 Systematic Optimization of Sandwich ELISA Microarray for Detection of Breast Cancer Biomarkers using Taguchi Design Luo W., Pla-Roca M., *Juncker D.
16:40 01862 Precursors of Ethanolamine Plasmalogen Biosynthesis Reduce Cholesterol Levels in Human Embryonic Kidney Cells *$Ahiahonu P. W. K., Mankidy R., Hong M., Jayasinghe D., Ritchie S., Wood P.L., Khan A.M., Goodenowe D.B. WITHDRAWN
17:00 End of Session

BM11Room 203 A

Protein Design and Engineering

Organizer(s) - Jumi Shin
Chair(s) - J. Shin

13:40 01863 New Approaches to Enzymatic Glycoside Synthesis Through Directed Evolution *$Withers S.G., Armstrong Z., Reitinger S., Hancock S., Aharoni A., Kim Y.-W., Rich J.R., Yang G.
14:20 01864 Minimalist DNA-binding Proteins from Rational Design and In Vivo Directed Evolution De Jong A.T., $Shin J.A.
14:40 01865 Halogenases: Better Living through 'Natural' Chemistry *$Zechel D.L.
15:00 01866 Engineering the Drug-binding Capacity of a Human Drug-target Enzyme *$Pelletier J.N., Gadler P., Volpato J.P., Guerrero V., Fossati E., Yachnin B.J., Berguis A.M.
15:40 Coffee Break
16:00 01867 Decoding Toxicity: Characterization of a Type I Toxin in Escherichia coli Mok W.K., *$Li Y.
16:20 01868 Probing the Active Site of Cystathionine b-Lyase Lodha P.H., *$Aitken S.M.
16:40 01869 Hemoglobin-Based Oxygen Carriers: Enhancing Nitrite Reductase Activity of Modified Hemoglobin Lui F.E., $Kluger R.
17:00 01870 Kinetic and Structural Studies of Highly Mutated Class A b-lactamases Clouthier C.M., Morin S., Gobeil S., Gagné S., *$Pelletier J.N.
17:20 01871 Engineering Fluorescent Proteins into New Biotools: Manipulation of Topology and Oligomerization $Campbell R.E.
18:00 End of Session

BM12Room 205 C

Radiopharmaceuticals (joint with OR9)

Organizer(s) - Neil Vasdev
Chair(s) - D. Abrams; D. Green

13:40 01872 Imaging Probe Discovery for Angiogenesis; From Rational to Random Design *$Luyt L.G.
14:20 01873 Challenging Radiochemistry: Useful Insights into the Radiosynthesis of [18F]Flumazenil Kostikov A., *$Schirrmacher R.
14:40 01874 Aqueous, Room Temperature 18F Chemistry: A Preliminary Evaluation of a New Prosthetic Approach *Inkster J.A.H., Pourghiasian M., Ait-Mohand S., Ruth T.J., Bénard F., Guérin B., Schaffer P., $Storr T.
15:00 01875 Production of High Specific Activity Isotopes for Radioimaging and Therapy at McMaster Nuclear Reactor *$Armstrong A.F.
15:40 Coffee Break
16:00 01876 Non-HPLC Methods for the Production of F-18, C-11 and Ga-68 Radiopharmaceuticals Yordanov A., Combs M., Stimson D., LeBars D., Shulman S., Soylu A., Bagci H., Mueller M.
16:20 01877 Biting the Bullet: Multi-Step Chemistry with Short-Lived Isotopes *$Vasdev N., Houle S., Wilson A.A.
17:00 End of Session

BM13Room 202 D

The Chemistry and Biology of Natural Products (joint with OR13)

Organizer(s) - Nathan Magarvey; Paul Harrison
Chair(s) - P. Harrison

13:40 See OR13

18:00 End of Session


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Bold text denotes the presenting author.   If present, * denotes the corresponding author and $ denotes the principal investigator.

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